(last update March 23rd, 2015)
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Tuesday
April 7 Evening
15:30 - 16:30 Registration
16:30 - 17:00 Welcome Cocktail
17:00 - 19:00 Symposium 1
The energy barrier for vesicle fusion
Chair: Matthijs Verhage (The Netherlands)
Erwin Neher (Germany) Modulation of short-term plasticity at the Calyx of Held synapse
Christian Rosenmund (Germany) Modulators of vesicle fusogenicity
Jakob B. Sørensen (Denmark) Phosphatidylinositol 4,5-Bisphosphate uncaging potentiates exocytosis by activating synaptotagmin
L. Niels Cornelisse (The Netherlands) Supralinear modulation of synaptic strength through additive effects on the energy barrier for vesicle fusion
19:00 - 19:45 Keynote Lecture 1
Josep Rizo (USA) Elucidating the molecular mechanism of neurotransmitter release
Wednesday
April 8 Morning
08:15 – 09:00 Keynote Lecture 2
Hongjun Song (USA) Single-cell analysis of adult neural stem cells and neurogenesis
09:00 - 11:00 Symposium 2
Neuronal stem cells in development and disease
Chair: Victor Tarabykin (Germany)
Freda D. Miller (Canada) Translational mechanisms regulating mammalian neurogenesis
Verdon Taylor (Switzerland) Molecular determination of quiescent and binary cell fate choices in adult neural stem cells
Angela M. Kaindl (Germany) Stem cells in a novel human mid-hindbrain malformation, microcephaly and intellectual disability phenotype
David R. Kaplan (Canada) Genes and drugs regulating stem cell function and repair
11:00 - 11:20 Coffee Break
11:20 - 13:20 Special Interest Session 1
Epigenetics and brain imaging: How do environmental and developmental factors influence behaviour?
Chair: Gunter Schumann (UK)
Sylvane Desrivieres (UK) Contributions of neurogenesis in human cognition: Cellular and MRI studies
Tomas Ekström (Sweden) The functional genome at the genetic-epigenetic-environment intersection
Georgy Bakalkin (Sweden) Locus-specific repressive DNA methylation as mechanism of neuron-specific gene transcription in the human brain: in-depth analysis of opioid genes
Gunter Schumann (UK) The effect of the environment on brain activity and behaviour: Characterisation of epigenetic mediators
Wednesday
April 8 Evening
16:00 – 18:00 Symposium 3
Structure and function of the synapse
Chairs: Stephan Sigrist (Germany) and Uri Ashery, (Israel)
Vladan Lucic (Germany) Quantitative analysis of synaptic structure by cryo-electron tomography
Benjamin Cooper (Germany) Molecular and morphological correlates of vesicle priming in neurosecretory cells
Stephan Sigrist (Germany) Shedding light on the functional organization of active zones
Uri Ashery (Israel) A combined optogenetic- knockdown strategy reveals a major role of tomosyn in mossy fiber synaptic plasticity
Timothy A. Ryan (USA) New layers of synaptic transmission control
18:00 - 18:20 Coffee Break
18:20 - 20:20 Symposium 4
Structural plasticity of perisynaptic astroglia
Chair: Dmitri Rusakov (UK)
Valentin Nägerl (France) Structure-function analysis of tripartite synapses
Yann Bernardinelli (Switzerland) Dynamics of astrocytic processes influence excitatory synapses stability
Alfonso Araque (Spain) Structural and functional plasticity of astrocyte process and dendritic spine interactions
Dmitri Rusakov (UK) Astroglia withdraw from synapses during LTP
Thursday
April 9 Morning
08:15 - 09:00 Keynote Lecture 3
Bernhard Bettler (Switzerland) Deconstructing GABAB receptors
09:00 - 11:00 Symposium 5
Trans-synaptic signaling
Chairs: Nils Brose (Germany) and Markus Missler (Germany)
Thomas Biederer (USA) Trans-synaptic SynCAM interactions organize synapse formation and neural network rewiring
Joris DeWit (Belgium) The sorting receptor SorCS1 interacts with neurexin and regulates synaptic proteome composition
Garret Anderson (USA) Beta-neurexin proteins at the synapse: Functional link with the endocannabinoid signaling system
Jürgen Klingauf (Germany), Markus Missler (Germany) Neuroligin-induced hippocampal synapses on functionalized micropatterns
Thursday
April 9 Evening
16:00 - 18:00 Symposium 6
Coordinated migration of excitatory and inhibitory neurons
Chairs: Annette Gaertner (Belgium) and Stephan Schwarzacher (Germany)
Laurent Nguyen (Belgium) MicroRNA targeting of CoREST controls polarization of migrating cortical neurons
Simon Hippenmeyer (Austria) Genetic dissection of neuronal migration using mosaic analysis with double markers
Christine Metin (France) Control of cortical interneuron migration by N-cadherin
Orly Reiner (Israel) Regulation of radial neuronal migration by polarity molecules
18:00 - 18:20 Coffee Break
18:20 - 20:20 Symposium 7
microRNAs in the nervous system - supported by the International Society for Neurochemistry
Chair: Michaela Kress (Austria)
Hermona Soreq (Israel) From mice to men: Fine tuning of cholinergic signaling by non-coding RNAs
Gerhard Schratt (Germany) microRNA function in synapse development and plasticity
Claudia Verderio (Italy) Glia-to-neuron shuttling of miR-146a via extracellular microvesicles modulates synaptotagmin I translation in neurons
Michaela Kress (Austria) microRNAs in nerve injury and neuropathic pain
Friday
April 10 Morning
08:15 - 09:00 Keynote Lecture 4
Alejandro Schinder (Argentina) A novel view of neurogenesis and memory encoding in the dentate gyrus
09:00 - 11:00 Symposium 8
Structural dynamics of adult neurogenesis
Chair: Stephan Schwarzacher (Germany) and Paul Lucassen (Netherlands)
Robert Hevner (US) Dentate Gyrus Development: A Movable Niche
Stephan Schwarzacher (Germany) Structural maturation and integration of adult newly generated hippocampal neurons: Is there
a critical phase?
Nora Abrous (France) Influence of spatial learning on development and structural maturation of newly formed neurons
Mirko Schmidt (Germany) The novel Notch ligand EGFL7 governs adult neurogenesis in vivo
Paul Lucassen (Netherlands) Adult neurogenesis: Structural plasticity in relation to stress and depression
11:00 - 11:20 Coffee Break
11:20 - 13:20 Special Interest Session 2
Hearing function and dysfunction in man and experimental animals - supported by TARGEAR, a project of the European Union FP7-People
Chair: Josef Syka (Czech Republic)
Wei Lui (Sweden) Ultrastructure and macromolecular organization of the human cochlea
Marlies Knipper (Germany) BDNF gathered cochlear driving force improves auditory fidelity, risking hyperactivity without gain after injury
Isabel Varela-Nieto (Spain) Age-related hearing loss: Apoptosis, autophagy and senescence: The role of IGF-1
Josef Syka (Czech Republic) Changes in the structure and function of the central auditory system with aging
Friday
April 10 Evening
16:00 - 16:45 Keynote Lecture 5
Moritz Helmsteadter (Germany) Connectomics: The dense reconstruction of neuronal circuits
16:45 - 17:05 Coffee Break
17:05 - 19:05 Symposium 9
Assembly and maintenance of the nodal complex in development, health and disease
Chair: Sue Barnett (UK)
Elior Peles (Israel) Assembly and maintenance of PNS nodes
Matthew Rasband (USA) Assembly and maintenance of CNS nodes
Jerome Devaux (France) Cell adhesion molecules at the nodal complex in health and disease
Hugh Willison (UK) Glycolipids at PNS and CNS nodes during maintenance and disease
19:05 - 20:00 Poster Session
20:00 Gala Dinner (free for Das Central hotel residents, others book at registration desk for 50,- € until Thursday evening)
Saturday
April 11 Morning
08:15 - 09:00 Keynote Lecture 6
Susanne Schoch (Germany) Transcriptional and epigenetic control of aberrant neuronal plasticity in epileptogenesis
09:00 - 09:30 Coffee Break
09:30 - 11:30 Symposium 10
Epigenetic mechanisms in epileptogenesis
Chair: Günther Sperk (Austria)
Katarzyna Lukasiuk (Poland) Methyl-CpG-binding domain protein 3 (MBD3) in the rat model of epilepsy
Katharina Kiese (Germany) Metabolic interference with epigenetic alterations in a rodent model of TLE
Christophe Bernard (France) Reprogramming of the hippocampal circadian clock in epilepsy
Günther Sperk (Austria) Changes in the expression of histone deacetylases in the hippocampus in models of temporal lobe epilepsy
Noora Puhakka (Finland) Chronic changes in microRNAa after after traumatic brain injury in the rat
11:30 End of meeting and departure