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Tuesday
April 9
15:00 – 16:30 Registration
16:30 - 17:00 Welcome Cocktail
17:00 - 19:00 Symposium 1
Multiple facets of serotonin receptors in regulation of brain functions
Chair: Evgeni Ponimaskin (Germany)
Vera Niederkofler (USA) Decoding the brain serotonergic system: Intersectional genetics and functional probing
Valerie Compan (France) Toggling the serotonin 5-HT4 receptors between active and silencing state switches motivation from restrictive diet towards overeating
Alexandre Dayer (Switzerland) Regulation of neuronal migration by the 5-HT6 receptor
Evgeni Ponimaskin (Germany) Development-dependent regulation of synaptogenesis and synaptic plasticity via serotonin receptors
Wednesday
April 10 Morning
08:15 – 09:00 Keynote Lecture 1
Peter Scheiffele (Switzerland) Molecular diversity, recognition, and synaptic differentiation
09:00 – 11:00 Symposium 2
Cell signaling in chronic diseases
Chair: Gregor Wenning (Austria)
Poul Henning Jensen (Denmark) Oligodendroglial degeneration in multiple systems atrophy – FAS and NF-kB related signaling
Timothy Bredy (Australia) Neocortical Tet3-mediated DNA hydroxymethylation promotes rapid behavioural adaptation
Nicolas Singewald (Austria) Vulnerability to emotional trauma: Novel treatment strategies
Jörg Striessnig (Austria) Voltage gated L-type calcium channels as drug targets in brain disorders
11:00 - 11:30 Coffee Break
11:30 - 13:30 Symposium 3
Regulation of growth factor signals during neuronal development and regeneration
Chair: Lars Klimaschewski (Austria)
Georg Dechant (Austria) Role of the chromatin organizer Satb2 in growth factor driven neuronal plasticity
Peter Claus (Germany) FGF signaling in neuronal development
Lars Klimaschewski (Austria) Novel approaches to accelerate axon elongation by enhancing FGF signaling
Karel Dorey (UK) Molecular and cellular mechanisms regulating axonal branching
Wednesday
April 10 Afternoon
16:00 – 16:45 Keynote Lecture 2
Pierre-Marie Lledo (France) Impact of adult neurogenesis on olfaction
16:45 – 17:15 Coffee Break
17:15 – 19:15 Symposium 4
Stem cells and adult neurogenesis
Chairs: Sebastian Jessberger (Switzerland) Stephan Schwarzacher (Germany)
Dieter Chichung Lie (Germany) SoxC transcription factors: Bifunctional regulators of adult neurogenesis
Verdon Taylor (Switzerland) Heterogeneous neural stem cells in health and regeneration
Sebastian Jessberger (Germany) Metabolic control of adult neural stem cell activity
Benedikt Berninger (Germany) Oligodendrogliogenic and neurogenic adult subependymal zone neural stem cells constitute distinct lineages and exhibit differential responsiveness to Wnt signaling
19:30 Gala Dinner (free for Das Central residents, others book at registration desk for 50,- €)
Thursday
April 11 Morning
08:15 – 09:00 Keynote Lecture 3
Michael Brecht (Germany) Social neural constructs in the rat barrel cortex
09:00 – 11:00 Symposium 5
ISN Symposium: Optogenetic control of motion and motivation
Chair: Ilka Diester (Germany)
IIka Diester (Germany) Optogenetics in the motor system
Ofer Yizhar (Israel) Optogenetic tool design and application in cortical microcircuits
Claire Wyart (France) Optogenetic dissection of spinal circuits underlying locomotion in vertebrates
Christian Lüscher (Switzerland) Optogenetics and addiction
11:00 - 11:30 Coffee Break
Thursday
April 11 Afternoon
16:00 – 18:00 Symposium 6
Mouse models for autism spectrum disorders
Chairs: Yuri Bozzi (Italy)
Michela Fagiolini (USA)
Michael Saxe (Switzerland) Rodent models of autism in drug discovery
Yuri Bozzi (Italy) GABAergic dysfunction in engrailed-2 mutant mice
Jennifer Brielmaier (USA) Pharmacological reversal of depression-related and social deficits in engrailed-2 knockout mice
Michela Fagiolini (USA) Circuit dissection in neurodevelopmental disorders
18:00 – 18:30 Coffee Break
18:30 – 20:30 Symposium 7
Altered synaptic function in mouse
models for autism spectrum disorders
Chairs: Tobias Böckers (Germany)
Carlo Sala (Italy)
Stephan Schwarzacher (Germany) Neuroligins as candidate genes for autism spectrum disorders: Regulation of synaptic activity and plasticity in vivo
Markus Missler (Germany) Towards a pathomechanism of autism: Regulation of synaptic function through Neurexophilin-1/a-Neurexin complex formation
Tobias Böckers (Germany) ProSAP/Shanks at the synapse: Function, dynamics and their role in autism spectrum disorders
Carlo Sala (Italy) The function of the X-linked intellectual disability IL1RAPL1 protein complex at synapses
Friday
April 12 Morning
08:15 – 09:00 Keynote Lecture 4
Botond Roska (Switzerland) Cell type specific computations in retina and cortex
09:00 – 11:00 Symposium 8
Reinforcement and decision making in the developing brain
Chair: Gunter Schumann (UK)
Georgy Bakalkin (Sweden) Shift in epigenetic regulation of opioid genes in brain of human alcoholics
Sylvane Desrivieres (UK) Identification and functional characterisation of neurodevelopmental genes involved in human cognition
Gunter Schumann (UK) A genome-wide association study of co-expression networks of brain activation during reward anticipation
11:00 - 11:30 Coffee Break
11:30 - 13:30 Symposium 9
Function of the auditory system - From the cochlea to auditory brainstem
Chair: Josef Syka (Czech Republic)
Pavel Mistrík and Jonathan Ashmore (UK) Molecular motor prestin in a cellular network and its role in sound amplification
Wei Liu (Sweden) The structure of human cochlea
Marlies Knipper (Germany) Learning about hearing from cell specific deletion of genes
Josef Syka (Czech Republic) Influence of postnatal acoustic stimulation on neuronal responsiveness in the adult auditory midbrain in rat
Friday
April 12 Afternoon
16:00 – 18:00 Symposium 10
Physiology of oxytocin and vasopressin in the central and peripheral system
Chair: Eva Sykova (Czech Republic)
Govindan Dayanithi (France)
Govindan Dayanithi (France) Calcium homeostasis in the hypothalamic vasopressin and oxytocin neurons and terminals
Eva Sykova (Czech Republic) Extrasynaptic volume transmission and diffusion parameters of the extracellular space
Hana Zemkova (Czech Republic) Potentiation of neurotransmitter release in neurons of supraoptic nuclus by presynaptic P2X receptors
Izumi Shibuya (Japan) Actions of vasopressin in dorsal root ganglion
18:00 – 19:30 Coffee and Poster Session
Saturday
April 13
08:15 – 09:00 Keynote Lecture 5
Karl Deisseroth (USA) Optical deconstruction of fully-assembled biological systems
09:00 – 09:30 Coffee Break
09:30 – 11:30 Symposium 11
Signal integration by astroglia: new insights
Chair: Dmitri Rusakov (UK)
Christian Steinhaeuser (Germany) Distinct astrocyte network communication in the thalamus
Alfonso Araque (Spain) Synaptic function regulated by astroglia via endocannabinoid and cholinergic signaling
Brian MacVicar (Canada) Neuron-Glia signaling to maintain a healthy brain
Dmitri Rusakov (UK) Deciphering key elements of Ca2+ signal processing in astrocytes
11:30 End of meeting and departure
Thursday
April 11 Morning
08:15 – 09:00 Keynote Lecture 3
Michael Brecht (Germany) Social neural constructs in the rat barrel cortex
09:00 – 11:00 Symposium 5
ISN Symposium: Optogenetic control of motion and motivation
Chair: Ilka Diester (Germany)
IIka Diester (Germany) Optogenetics in the motor system
Ofer Yizhar (Israel) Optogenetic tool design and application in cortical microcircuits
Claire Wyart (France) Optogenetic dissection of spinal circuits underlying locomotion in vertebrates
Christian Lüscher (Switzerland) Optogenetics and addiction
11:00 - 11:30 Coffee Break
Thursday
April 11 Afternoon
16:00 – 18:00 Symposium 6
Mouse models for autism spectrum disorders
Chairs: Yuri Bozzi (Italy)
Michela Fagiolini (USA)
Michael Saxe (Switzerland) Rodent models of autism in drug discovery
Yuri Bozzi (Italy) GABAergic dysfunction in engrailed-2 mutant mice
Jennifer Brielmaier (USA) Pharmacological reversal of depression-related and social deficits in engrailed-2 knockout mice
Michela Fagiolini (USA) Circuit dissection in neurodevelopmental disorders
18:00 – 18:30 Coffee Break
18:30 – 20:30 Symposium 7
Altered synaptic function in mouse
models for autism spectrum disorders
Chairs: Tobias Böckers (Germany)
Carlo Sala (Italy)
Stephan Schwarzacher (Germany) Neuroligins as candidate genes for autism spectrum disorders: Regulation of synaptic activity and plasticity in vivo
Markus Missler (Germany) Towards a pathomechanism of autism: Regulation of synaptic function through Neurexophilin-1/a-Neurexin complex formation
Tobias Böckers (Germany) ProSAP/Shanks at the synapse: Function, dynamics and their role in autism spectrum disorders
Carlo Sala (Italy) The function of the X-linked intellectual disability IL1RAPL1 protein complex at synapses